diff --git a/tfm_ci_pylib/tfm_build_manager.py b/tfm_ci_pylib/tfm_build_manager.py
index 7721a8c..75a2cd8 100644
--- a/tfm_ci_pylib/tfm_build_manager.py
+++ b/tfm_ci_pylib/tfm_build_manager.py
@@ -418,6 +418,11 @@
         build_cfg["nspe_cmake_build"] %= overwrite_params
         build_cfg["post_build"] %= overwrite_params
 
+        # Disable NSPE CMake commands when NS is OFF
+        if "NSOFF" in i.extra_params:
+            build_cfg["nspe_config_template"] = ""
+            build_cfg["nspe_cmake_build"] = ""
+
         return build_cfg
 
     def post_eval(self):